Xenobiotic-metabolizing enzymes as autoantigens in human autoimmune disorders - An update

被引：11

作者：

Boitier, E ^{[1
]}

Beaune, P ^{[1
]}

机构：

[1] Univ Paris 05, INSERM, U490, Paris 06, France

来源：

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 2000年 / 18卷 / 02期

关键词：

D O I：

10.1385/CRIAI:18:2:215

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Several diseases are characterized by the presence of autoantibodies directed against either CYP or xenobiotic-metabolizing enzymes. They may be induced by toxic or idiopathic event. Very little is known about the mechanism of their triggering. When a toxic compound was identified, the metabolic part was quite well-characterized and variations of metabolism could be a risk factor in the development of the disease (e.g., dihydralazine-induced hepatitis). But in all the cases the abnormal immunological response is not understood, although it seems clear that the autoantibodies are not by themselves responsible for the disease.

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页码：215 / 239

页数：25

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