Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones

被引：77

作者：

Zhao, XL

Wang, JY

Xu, C

Dong, YZ

Zhou, JF

Domagala, J

Drlica, K

机构：

[1] Publ Hlth Res Inst City New York Inc, New York, NY 10016 USA

[2] Warner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Ann Arbor, MI 48105 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 04期

关键词：

D O I：

10.1128/AAC.42.4.956

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.

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收藏

页码：956 / 958

页数：3

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