Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones

被引:77
作者
Zhao, XL
Wang, JY
Xu, C
Dong, YZ
Zhou, JF
Domagala, J
Drlica, K
机构
[1] Publ Hlth Res Inst City New York Inc, New York, NY 10016 USA
[2] Warner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Ann Arbor, MI 48105 USA
关键词
D O I
10.1128/AAC.42.4.956
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.
引用
收藏
页码:956 / 958
页数:3
相关论文
共 21 条
[1]   COMPARATIVE INVITRO ACTIVITIES OF THE NEW QUINOLONE, BAY-Y-3118, AND CIPROFLOXACIN, SPARFLOXACIN, TOSUFLOXACIN, CI-960 AND CI-990 [J].
BAUERNFEIND, A .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1993, 31 (04) :505-522
[2]   DNA gyrase and topoisomerase IV on the bacterial chromosome: Quinolone-induced DNA cleavage [J].
Chen, CR ;
Malik, M ;
Snyder, M ;
Drlica, K .
JOURNAL OF MOLECULAR BIOLOGY, 1996, 258 (04) :627-637
[3]   IN-VITRO AND IN-VIVO ACTIVITIES OF CLINAFLOXACIN, CI-990 (PD-131112), AND PD-138312 VERSUS ENTEROCOCCI [J].
COHEN, MA ;
YODER, SL ;
HUBAND, MD ;
ROLAND, GE ;
COURTNEY, CL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (09) :2123-2127
[4]   Antibacterial activity and pharmacokinetics of four new 7-azetidinyl fluoroquinolones [J].
Coll, R ;
GargalloViola, D ;
Tudela, E ;
Xicota, MA ;
Llovera, S ;
Guinea, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (01) :274-277
[5]   MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI .3. CONDITIONS REQUIRED FOR LETHALITY [J].
DEITZ, WH ;
COOK, TM ;
GOSS, WA .
JOURNAL OF BACTERIOLOGY, 1966, 91 (02) :768-&
[6]   DNA gyrase, topoisomerase IV, and the 4-quinolones [J].
Drlica, K ;
Zhao, XL .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1997, 61 (03) :377-+
[7]   CLONING AND PRIMARY STRUCTURE OF STAPHYLOCOCCUS-AUREUS DNA TOPOISOMERASE-IV - A PRIMARY TARGET OF FLUOROQUINOLONES [J].
FERRERO, L ;
CAMERON, B ;
MANSE, B ;
LAGNEAUX, D ;
CROUZET, J ;
FAMECHON, A ;
BLANCHE, F .
MOLECULAR MICROBIOLOGY, 1994, 13 (04) :641-653
[8]   ANALYSIS OF GYRA AND GRLA MUTATIONS IN STEPWISE-SELECTED CIPROFLOXACIN-RESISTANT MUTANTS OF STAPHYLOCOCCUS-AUREUS [J].
FERRERO, L ;
CAMERON, B ;
CROUZET, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (07) :1554-1558
[9]  
FISHER LM, 1993, MOLECULAR BIOLOGY OF DNA TOPOISOMERASES AND ITS APPLICATION CHEMOTHERAPY, P145
[10]   Nonadaptive mutations occur on the F' episome during adaptive mutation conditions in Escherichia coli [J].
Foster, PL .
JOURNAL OF BACTERIOLOGY, 1997, 179 (05) :1550-1554