The integrin-actin connection, an eternal love affair

被引：364

作者：

Brakebusch, C ^{[1
]}

Fässler, R ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Med, D-82152 Martinsried, Germany

来源：

EMBO JOURNAL | 2003年 / 22卷 / 10期

关键词：

actin; focal adhesion; ILK-PINCH-parvin complex; integrin; integrin signalling;

D O I：

10.1093/emboj/cdg245

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction can be viewed as a cyclical liaison, which develops again and again at new adhesion sites only to cease at sites of de-adhesion. Recent work has demonstrated that multidomain proteins play crucial roles in the integrin-actin connection by providing a high degree of regulation adjusted to the needs of the cell. In this review we present several examples of this paradigm and with special emphasis on the ILK-PINCH-parvin complex, which amply demonstrates how structural and signalling functions are linked together.

引用

页码：2324 / 2333

页数：10

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