A thiyl radical mediated cascade sequence for the co-cyclisation of 1,6-hexadienes with sulfur atom transfer

被引：17

作者：

Harrowven, DC ^{[1
]}

Hannam, JC

Lucas, MC

Newman, NA

Howes, PD

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[2] GlaxoWellcome Med Res Ctr, Med Chem 2, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 48期

基金：

英国工程与自然科学研究理事会;

关键词：

cyclisations; photochemistry; radicals and radical reactions; sulfur heterocycles;

D O I：

10.1016/S0040-4039(00)01701-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The paper describes a method for effecting the co-cyclisation of 1,6-dienes with concomitant sulfur atom transfer. The key step is a cascade reaction involving the addition of a thiyl radical to an alkene, cyclisation through a chair-like transition state and termination by homolytic substitution at sulfur. It has been used to synthesise a broad range of fused thiabicyclo[3.3.0]octanes. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9345 / 9349

页数：5

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