MAPK phosphatases - regulating the immune response

被引：558

作者：

Liu, Yusen ^{[1
]}

Shepherd, Edward G. ^{[1
]}

Nelin, Leif D. ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Perinatal Res, Columbus Childrens Res Inst, Childrens Hosp,Dept Pediat,Coll Med, Columbus, OH 43205 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2035

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are protein phosphatases that dephosphorylate both the phosphothreonine and phosphotyrosine residues on activated MAPKs. Removal of the phosphates renders MAPKs inactive, effectively halting their cellular function. In recent years, evidence has emerged that, similar to MAPKs, MKPs are pivotal in the regulation of immune responses. By deactivating MAPKs, MKPs can modulate both innate and adaptive immunity. A number of immunomodulatory agents have been found to influence the expression of MKP1 in particular, highlighting the central role of this phosphatase in immune regulation. This Review discusses the properties, function and regulation of MKPs during immune responses.

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页码：202 / 212

页数：11

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