Ischemia and iscchemic tolerence in the brain: an overview

被引：58

作者：

Zemke, D

Smith, JL

Reeves, MJ

Majid, A ^{[1
]}

机构：

[1] Michigan State Univ, Dept Neurol & Ophthalmol, E Lansing, MI 48824 USA

[2] Michigan State Univ, Program Neurosci, E Lansing, MI 48824 USA

[3] Michigan State Univ, Dept Epidemiol, E Lansing, MI 48824 USA

来源：

NEUROTOXICOLOGY | 2004年 / 25卷 / 06期

关键词：

stroke; ischemia; tolerance; preconditioning;

D O I：

10.1016/j.neuro.2004.03.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Stroke is the third leading cause of death and the leading cause of adult disability in the United States. This review outlines the pathways that lead to cell death following stroke, and also summarizes the current literature on the phenomenon of ischemic tolerance. Ischemic tolerance is an endogenous neuroprotective mechanism by which neurons are protected from the deleterious effects of brain ischemia that occur during and after stroke. A better understanding of the processes that lead to cell death after stroke and endogenous neuroprotective mechanisms like ischemic tolerance could help in the development of new treatment strategies for this devastating neurological disease. (C) 2004 Elsevier Inc. All rights reserved.

引用

收藏

页码：895 / 904

页数：10

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