Challenges for clinical trials to treat progressive multifocal leukoencephalopathy

被引:5
作者
Clifford, DB [1 ]
机构
[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
关键词
AIDS; HIV; human immunodeficiency virus; JC virus; PML; progressive multifocal leukoencephalopathy;
D O I
10.1080/713831420
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Progressive multifocal leukoencephalopathy is a lethal complication of immunodeficiency for which no direct therapy has been achieved. The issues that have made this disease especially difficult to address are discussed, and an outline for development of future interventions is provided. A controlled trial of therapy utilizing an international group of trial groups is proposed.
引用
收藏
页码:68 / 72
页数:5
相关论文
共 19 条
[1]  
ANTINORI A, 2001, 8 C RETR OPP INF CHI
[2]   A combination of low-dose chlorpromazine and neutralizing antibodies inhibits the spread of JC virus (JCV) in a tissue culture model: Implications for prophylactic and therapeutic treatment of progressive multifocal leukencephalopathy [J].
Atwood, WJ .
JOURNAL OF NEUROVIROLOGY, 2001, 7 (04) :307-310
[3]   Predictive factors for prolonged survival in acquired immunodeficiency syndrome-associated progressive multifocal leukoencephalopathy [J].
Berger, JR ;
Levy, RM ;
Flomenhoft, D ;
Dobbs, M .
ANNALS OF NEUROLOGY, 1998, 44 (03) :341-349
[4]  
Cinque P, 1998, NEW ENGL J MED, V339, P848, DOI 10.1056/NEJM199809173391216
[5]  
Clifford DB, 1998, NEUROLOGY, V50, pA249
[6]   HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy [J].
Clifford, DB ;
Yiannoutsos, C ;
Glicksman, M ;
Simpson, DM ;
Singer, EJ ;
Piliero, PJ ;
Marra, CM ;
Francis, GS ;
McArthur, JC ;
Tyler, KL ;
Tselis, AC ;
Hyslop, NE .
NEUROLOGY, 1999, 52 (03) :623-625
[7]   Progressive multifocal leukoencephalopathy: Improved survival of human immunodeficiency virus-infected patients in the protease inhibitor era [J].
Dworkin, MS ;
Wan, PCT ;
Hanson, DL ;
Jones, JL .
JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (03) :621-625
[8]  
Geschwind MD, 2001, J NEUROVIROL, V7, P353
[9]   Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy:: Effects on cerebrospinal fluid markers of JC virus replication and immune response [J].
Giudici, B ;
Vaz, B ;
Bossolasco, S ;
Casari, S ;
Brambilla, AM ;
Lüke, W ;
Lazzarin, A ;
Weber, T ;
Cinque, P .
CLINICAL INFECTIOUS DISEASES, 2000, 30 (01) :95-99
[10]   Failure of cytarabine in progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection [J].
Hall, CD ;
Dafni, U ;
Simpson, D ;
Clifford, D ;
Wetherill, PE ;
Cohen, B ;
McArthur, J ;
Hollander, H ;
Yainnoutsos, C ;
Major, E ;
Millar, L ;
Timpone, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (19) :1345-1351