New ruthenium catalysts for asymmetric transfer hydrogenation of prochiral ketones

被引：88

作者：

Enthaler, Stephan ^{[1
]}

Hagemann, Bernhard ^{[1
]}

Bhor, Santosh ^{[1
]}

Anilkumar, Gopinathan ^{[1
]}

Tse, Man Kin ^{[1
]}

Bitterlich, Bianca ^{[1
]}

Junge, Kathrin ^{[1
]}

Erre, Giulia ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 06期

关键词：

asymmetric transfer hydrogenation; ketones; phosphines; ruthenium; tridentate nitrogen; ligands;

D O I：

10.1002/adsc.200600475

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Tridentate N,N,N-pyridinebisimidazolines have been studied as new ligands for the enantioselective transfer hydrogenation of prochiral ketones. High yields and excellent enantioselectivity up to > 99 % ee have been achieved with an in situ generated catalytic system containing dichlorotris(triphenylphosphine)ruthenium and 2,6-bis-([4R,5R]-4,5diphenyl-4,5-dihydro-1 H-imidazol-2-yl)-pyridine (3a) in the presence of sodium isopropoxide.

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页码：853 / 860

页数：8

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