Dietary fat attenuates the benefits of an elemental diet in active Crohn's disease: a randomized, controlled trial

被引:74
作者
Bamba, T
Shimoyama, T
Sasaki, M
Tsujikawa, T [1 ]
Fukuda, Y
Koganei, K
Hibi, T
Iwao, Y
Munakata, A
Fukuda, S
Matsumoto, T
Oshitani, N
Hiwatashi, N
Oriuchi, T
Kitahora, T
Utsunomiya, T
Saitoh, Y
Suzuki, Y
Nakajima, M
机构
[1] Shiga Univ Med Sci, Dept Internal Med 2, Shiga 5202192, Japan
[2] Hyogo Med Univ, Dept Internal Med 4, Nishinomiya, Hyogo, Japan
[3] Yokohama City Hosp, Dept Surg, Kanagawa, Japan
[4] Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
[5] Hirosaki Univ, Sch Med, Dept Internal Med 1, Hirosaki, Aomori, Japan
[6] Osaka City Univ, Sch Med, Dept Internal Med 3, Osaka 545, Japan
[7] Tohoku Univ, Sch Med, Dept Internal Med 3, Sendai, Miyagi 980, Japan
[8] Natl Ohkura Hosp, Inst Clin Res, Tokyo, Japan
[9] Chiba Univ, Sch Med, Dept Internal Med 2, Chiba 280, Japan
[10] Hamamatsu Univ Sch Med, Dept Pharmacol, Shizuoka, Japan
关键词
elemental diet; dietary fat; Crohn's disease; International Organization of Inflammatory Bowel Disease;
D O I
10.1097/00042737-200302000-00008
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives Although an elemental diet has been established as the primary treatment for patients with Crohn's disease, the influence of dietary fat on the elemental diet remains unclear. We have designed the first randomized, controlled trial for elemental diets containing different fat percentages in patients with active Crohn's disease. Methods Each patient was randomized to receive one of three dose levels of fat in an elemental diet (Elental) for 4 weeks: 10 patients received low fat (3.06 g/day), 10 patients received medium fat (116.56 g/day) and eight patients received high fat (30.06 g/day). The additional fat was composed of long-chain fatty acids. All patients were evaluated using the International Organization of Inflammatory Bowel Disease rating, plus C-reactive protein level and erythrocyte sedimentation rate, which were measured at weekly intervals. Results Although the International Organization of Inflammatory Bowel Disease rating, C-reactive protein level and erythrocyte sedimentation rate in the low-fat group decreased, the values in the medium- and high-fat groups fluctuated during the study. The remission rate after 4 weeks in each group was 80%, 40% and 25% for patients in the low-, medium- and high-fat groups, respectively. Conclusions When the fat consisted of long-chain triglycerides, a high amount of this fat in the elemental diet formula decreased its therapeutic effect against active Crohn's disease.
引用
收藏
页码:151 / 157
页数:7
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