Epigenomic regulation of host-microbiota interactions

被引：47

作者：

Alenghat, Theresa ^{[1
]}

Artis, David ^{[2
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Div Immunol, Cincinnati, OH 45229 USA

[2] Cornell Univ, Weill Cornell Med Coll, New York, NY 10022 USA

来源：

TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 11期

基金：

美国国家卫生研究院;

关键词：

CHAIN FATTY-ACIDS; INTESTINAL EPITHELIAL-CELLS; HISTONE DEACETYLASE INHIBITORS; NUCLEAR RECEPTOR COREPRESSOR; INFLAMMATORY-BOWEL-DISEASE; INNATE IMMUNE-RESPONSES; GUT MICROBIOTA; COMMENSAL-BACTERIA; T-CELLS; CHROMATIN-STRUCTURE;

D O I：

10.1016/j.it.2014.09.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The trillions of beneficial commensal microorganisms that normally reside in the gastrointestinal tract have emerged as a critical source of environmentally-derived stimuli that can impact health and disease. However, the underlying cellular and molecular mechanisms that recognize commensal bacteria-derived signals and regulate mammalian homeostasis are just beginning to be defined. Highly coordinated epigenomic modifications allow mammals to alter the transcriptional program of a cell in response to environmental cues. These modifications may play a key role in regulating the dynamic relationship between mammals and their microbiota. We review recent advances in understanding the interplay between the microbiota and mammalian epigenomic pathways, and highlight emerging findings that implicate a central role for histone deacetylases (HDACs) in orchestrating host microbiota interactions.

引用

页码：518 / 525

页数：8

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