Synthesis of a C1-C9 fragment of rhizoxin

被引：19

作者：

Davenport, RJ ^{[1
]}

Regan, AC ^{[1
]}

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(00)01337-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A C1-C9 fragment of the antitumour macrolide rhizoxin has been synthesised. An Evans' asymmetric aldol reaction was used to set up the first two chiral centres, and an alpha,beta-unsaturated delta-lactone was then formed on the acyclic system by an intramolecular Wadsworth-Emmons reaction. Stereoselective hydrogenation was used to set up the cts relative stereochemistry in the saturated delta-lactone ring. (C) 2000 Published by Elsevier Science Ltd.

引用

页码：7619 / 7622

页数：4

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