学术探索
学术期刊
新闻热点
数据分析
智能评审

Synthetic arabinofuranosyl oligosaccharides as mycobacterial arabinosyltransferase substrates

被引：59
作者：
Ayers, JD
Lowary, TL
Morehouse, CB
Besra, GS
机构：
[1] Ohio State Univ, Dept Chem, Columbus, OH 43202 USA
[2] Colorado State Univ, Dept Microbiol, Ft Collins, CO 80523 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0960-894X(98)00049-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of arabinofuranosyl oligosaccharides found as constituent parts of the polysaccharide portion of the cell wall of Mycobacterium tuberculosis have been chemically synthesized. Screening of these oligosaccharides as substrates for arabinosyltransferases present in mycobacterial membrane preparations suggests that modified oligosaccharide analogs as small as disaccharides may be inhibitors of glycan biosynthesis. Such inhibitors would be of potential utility as lead compounds in the identification of new drugs for the treatment of mycobacterial infections. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：437 / 442
页数：6
相关论文
共 22 条
  • [1] BACKINOWSKY LV, 1986, CARBOHYD RES, V137, pC1
  • [2] Molecular mechanisms of drug resistance in Mycobacterium tuberculosis
    Blanchard, JS
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1996, 65 : 215 - 239
  • [3] TUBERCULOSIS - COMMENTARY ON A REEMERGENT KILLER
    BLOOM, BR
    MURRAY, CJL
    [J]. SCIENCE, 1992, 257 (5073) : 1055 - 1064
  • [4] Structure, function and biogenesis of the mycobacterial cell wall
    Brennan, PJ
    Besra, GS
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1997, 25 (01) : 188 - 194
  • [5] THE ENVELOPE OF MYCOBACTERIA
    BRENNAN, PJ
    NIKAIDO, H
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1995, 64 : 29 - 63
  • [6] RECOGNITION OF MULTIPLE EFFECTS OF ETHAMBUTOL ON METABOLISM OF MYCOBACTERIAL CELL-ENVELOPE
    DENG, LY
    MIKUSOVA, K
    ROBUCK, KG
    SCHERMAN, M
    BRENNAN, PJ
    MCNEIL, MR
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (03) : 694 - 701
  • [7] DOLIN PJ, 1994, B WORLD HEALTH ORGAN, V72, P213
  • [8] GILBERG SL, 1996, MED J AUSTRALIA, V154, P121
  • [9] GENERAL METHOD OF SYNTHESIS AND ISOLATION, AND AN NMR-SPECTROSCOPIC STUDY, OF "TETRA-O-ACETYL-D-ALDOPENTOFURANOSES
    KAM, BL
    BARASCUT, JL
    IMBACH, JL
    [J]. CARBOHYDRATE RESEARCH, 1979, 69 (MAR) : 135 - 142
  • [10] THE CORE TRISACCHARIDE OF ALPHA-L-ARABINOFURANAN - SYNTHESIS OF METHYL 3,5-DI-O-ALPHA-L-ARABINOFURANOSYL-ALPHA-L-ARABINOFURANOSIDE
    KANEKO, S
    KAWABATA, Y
    ISHII, T
    GAMA, Y
    KUSAKABE, I
    [J]. CARBOHYDRATE RESEARCH, 1995, 268 (02) : 307 - 311
123