Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population

被引:34
作者
Gomez, L. M.
Sanchez, E.
Ruiz-Narvaez, E. A.
Lopez-Nevot, M. A.
Anaya, J.-M.
Martin, J.
机构
[1] CIB, Cellular Biol & Immunogenet Unit, Medellin, Colombia
[2] CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada, Spain
[3] Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA
[4] Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[5] Hosp Virgen Nieves, Serv Inmunol, Granada, Spain
[6] Univ Rosario, Sch Med, Medellin, Colombia
来源
TISSUE ANTIGENS | 2007年 / 70卷 / 01期
关键词
delayed-type hypersensitivity; microsatellite; MIF; polymorphism; single nucleotide; tuberculin skin test; tuberculosis;
D O I
10.1111/j.1399-0039.2007.00843.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptative immunity responses against pathogens. The MIF gene, at 22q11.2, is polymorphic. Functional promoter variants in the MIF gene influence susceptibility to inflammatory diseases in Caucasians and Africans. An association study was carried out to examine the influence of MIF-173 single nucleotide polymorphism and the MIF-794 microsatellite on the susceptibility to develop human tuberculosis (TB) in a well-defined Latin-American population. To this purpose, 230 northwestern Colombian patients with pulmonary TB, negative for human immunodeficiency virus infection, and 235 matched healthy individuals stratified by the tuberculin skin test were examined. Multivariate analysis showed that MIF-173C allele was associated with disease (odds ratio = 1.64, 95% confidence interval 1.07-2.52) in a dominant pattern. No allele in the MIF-794 CATT microsatellite was associated with risk of TB. These results indicate that MIF gene influences the risk of developing TB in the studied population.
引用
收藏
页码:28 / 33
页数:6
相关论文
共 34 条
[1]   A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria [J].
Awandare, G. A. ;
Ouma, C. ;
Keller, C. C. ;
Were, T. ;
Otieno, R. ;
Ouma, Y. ;
Davenport, G. C. ;
Hittner, J. B. ;
Ong'echa, J. M. ;
Ferrell, R. ;
Perkins, D. J. .
GENES AND IMMUNITY, 2006, 7 (07) :568-575
[2]   A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis [J].
Baugh, JA ;
Chitnis, S ;
Donnelly, SC ;
Monteiro, J ;
Lin, X ;
Plant, BJ ;
Wolfe, F ;
Gregersen, PK ;
Bucala, R .
GENES AND IMMUNITY, 2002, 3 (03) :170-176
[3]   Genetic susceptibility to tuberculosis [J].
Bellamy, R .
CLINICS IN CHEST MEDICINE, 2005, 26 (02) :233-+
[4]   Susceptibility to mycobacterial infections: the importance of host genetics [J].
Bellamy, R .
GENES AND IMMUNITY, 2003, 4 (01) :4-11
[5]   Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene [J].
Bellamy, R ;
Ruwende, C ;
Corrah, T ;
McAdam, KPWJ ;
Thursz, M ;
Whittle, HC ;
Hill, AVS .
JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (03) :721-724
[6]  
BELLAMY R, N ENGL J MED, V338, P640
[7]   MIF IS A PITUITARY-DERIVED CYTOKINE THAT POTENTIATES LETHAL ENDOTOXEMIA [J].
BERNHAGEN, J ;
CALANDRA, T ;
MITCHELL, RA ;
MARTIN, SB ;
TRACEY, KJ ;
VOELTER, W ;
MANOGUE, KR ;
CERAMI, A ;
BUCALA, R .
NATURE, 1993, 365 (6448) :756-759
[8]   An essential role for macrophage migration inhibitory factor in the tuberculin delayed-type hypersensitivity reaction [J].
Bernhagen, J ;
Bacher, M ;
Calandra, T ;
Metz, CN ;
Doty, SB ;
Donnelly, T ;
Bucala, R .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (01) :277-282
[9]   ASSOCIATION OF TUBERCULOSIS AND M-TUBERCULOSIS-SPECIFIC ANTIBODY-LEVELS WITH HLA [J].
BOTHAMLEY, GH ;
BECK, JS ;
SCHREUDER, GMT ;
DAMARO, J ;
DEVRIES, RRP ;
KARDJITO, T ;
IVANYI, J .
JOURNAL OF INFECTIOUS DISEASES, 1989, 159 (03) :549-555
[10]   MACROPHAGE IS AN IMPORTANT AND PREVIOUSLY UNRECOGNIZED SOURCE OF MACROPHAGE-MIGRATION INHIBITORY FACTOR [J].
CALANDRA, T ;
BERNHAGEN, J ;
MITCHELL, RA ;
BUCALA, R .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (06) :1895-1902