Interplay between influenza A virus and the innate immune signaling

被引：99

作者：

Ehrhardt, Christina ^{[1
]}

Seyer, Roman ^{[1
]}

Hrincius, Eike R. ^{[1
]}

Eierhoff, Thorsten ^{[1
]}

Wolff, Thorsten ^{[2
]}

Ludwig, Stephan ^{[1
]}

机构：

[1] Univ Munster, Inst Mol Virol, Ctr Mol Biol Inflammat ZMBE, D-48149 Munster, Germany

[2] Robert Koch Inst, D-13353 Berlin, Germany

来源：

MICROBES AND INFECTION | 2010年 / 12卷 / 01期

关键词：

Influenza virus; Innate immune signaling; Antiviral defense; INTERFERON REGULATORY FACTOR-3; TRIM FAMILY PROTEINS; DOUBLE-STRANDED-RNA; NS1; PROTEIN; RIG-I; ANTIVIRAL RESPONSES; UBIQUITIN LIGASE; AVIAN INFLUENZA; INFECTED-CELLS; ACTIVATION;

D O I：

10.1016/j.micinf.2009.09.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pathogens such as influenza A viruses (IAV) have to overcome a number of barriers defined and maintained by the host, to successfully establish an infection. One of the initial barriers is collectively characterized as the innate immune system. This is a broad anti-pathogen defense program that ranges from the action of natural killer cells to the induction of an antiviral cytokine response. In this article we will focus on new developments and discoveries concerning the interaction of IAV with the cellular innate immune signaling. We discuss new mechanisms of interference of IAV with the pathogen recognition receptor RIG-I and the type I IFN antagonist NS1 in the background of already known and established concepts. Further we summarize progress related to recently identified IFN induced proteins and the role of RNA interference in the context of IAV infection. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：81 / 87

页数：7

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