Interleukin-18 (IL-18) and infectious diseases, with special emphasis on diseases induced by intracellular pathogens

被引：50

作者：

Sugawara, I ^{[1
]}

机构：

[1] Japan Antitubererculosis Assoc, Res Inst Tuberculosis, Dept Mol Pathol, Tokyo 2040022, Japan

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 10期

关键词：

IL-18; infectious diseases; intracellular pathogens;

D O I：

10.1016/S1286-4579(00)01279-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-18 (IL-18) is a novel cytokine mainly produced by activated macrophages. IL-18 was originally called interferon-gamma inducing factor, due to its action in inducing IFN-gamma secretion from Th1 cells, NK cells and NKT cells. It has been reported that IL-18 may play important roles in various diseases including cancer and infectious diseases. This review deals with the roles of IL-18 in infectious diseases, with special emphasis on IL-18 in infectious diseases caused by intracellular pathogens including Mycobacterium tuberculosis, Mycobacterium leprae, Listeria monocytogenes and Salmonella typhimurium. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：1257 / 1263

页数：7

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