The profile of the cytokines secreted during the generation of T-helper cells from atopic asthmatic subjects

被引：5

作者：

Crocker, IC ^{[1
]}

Gupta, K ^{[1
]}

Townley, RG ^{[1
]}

Khan, MM ^{[1
]}

机构：

[1] Creighton Univ, Hlth Sci Ctr, Dept Pharmaceut Sci, Omaha, NE 68178 USA

来源：

JOURNAL OF ASTHMA | 1998年 / 35卷 / 02期

关键词：

D O I：

10.3109/02770909809068207

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This study investigated cytokine release by T-cell lines from atopic and nonatopic individuals in the presence of specific aeroallergen. Cell lines from atopic and nonatopic individuals secreted IL-2 for less than 14 and more than 21 days, respectively. All of the atopic, but not the nonatopic, cell lines exhibited a biphasic peak in IL-4 and IL-5 secretion. Flow cytometry revealed that, after 35 days, 89.3% of the atopic cells were T helpers and 73.2% were activated. Only 7.4% of the nonatopic cells displayed activation markers. In conclusion, T-cell differentiation may be controlled by other factors in addition to stimulation by aeroallergens.

引用

页码：187 / 201

页数：15

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