The exon-intron architecture of human chloride channel genes is not conserved

被引：3

作者：

Eggermont, J ^{[1
]}

机构：

[1] Catholic Univ Louvain, Fysiol Lab, B-3000 Louvain, Belgium

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1397卷 / 02期

关键词：

chloride channel; splicing; gene structure; exon;

D O I：

10.1016/S0167-4781(98)00014-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human CLCN6 gene contains a 167 bp exon that is optionally included or excluded in ClC-6 mRNAs. The corresponding region (3.4 kbp) of the human CLCN7 gene has now been cloned and sequenced. a comparison of the human CLCN1, CLCN5, CLCN6 and CLCN7 genes indicates that there is no homologue of the optional CLCN6 exon in the CLCN1, CLCN5 or CLCN7 genes, Thus, the CLCN6 type of alternative splicing and the ensuing structural diversity is not conserved within the CLC gene family. (C) 1998 Elsevier Science B.V.

引用

页码：156 / 160

页数：5

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