Derivatization in mass spectrometry - 1. Silylation

被引:186
作者
Halket, JM
Zaikin, VG
机构
[1] Kings Coll London, Drug Control Ctr, London SE1 9NN, England
[2] Russian Acad Sci, Topchiev Inst Petrochem Synth, Moscow, Russia
关键词
silylation; silyl derivatives; silyl agents; mass spectrometry; electron ionization; chemical ionization; gas chromatography/mass spectrometry; alcohols; phenols; carboxylic acids; oximes; phosphorous acids; thiols; amines; amides; steroids; amino acids; doping control; urine analysis;
D O I
10.1255/ejms.527
中图分类号
O64 [物理化学(理论化学)、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号
070203 ; 070304 ; 081704 ; 1406 ;
摘要
This is the first of a series of reviews on the application of derivatization in mass spectrometry. A description is given of advances in silylation as a powerful tool used for increasing the volatility, thermal and thermo-catalytic stability, and chromatographic mobility of polar and unstable organic compounds. In addition to chemical aspects of silylation, mass spectral properties of silyl derivatives useful for structure determination and quantitation of various organic and biologically-active compounds, mainly by GC/MS, are described. Practically all tested and widely used silylating agents are described. The role of comprehensive libraries containing reference mass spectra for various silyl derivatives and search systems in structure determination is emphasized. Applications of silylation for particular analyses are summarised.
引用
收藏
页码:1 / 21
页数:21
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