NF-κB in cancer:: From innocent bystander to major culprit

被引：2153

作者：

Karin, M ^{[1
]}

Cao, YX ^{[1
]}

Greten, FR ^{[1
]}

Li, ZW ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc780

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nuclear factor of kappaB (NF-kappaB) is a sequence-specific transcription factor that is known to be involved in the inflammatory and innate immune responses. Although the importance of NF-kappaB in immunity is undisputed, recent evidence indicates that NF-kappaB and the signalling pathways that are involved in its activation are also important for tumour development. NF-kappaB should therefore receive as much attention from cancer researchers as it has already from immunologists.

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收藏

页码：301 / 310

页数：10

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