Inducing stroke in aged, hypertensive, diabetic rats

被引：29

作者：

Rewell, Sarah S. J.

Fernandez, John A.

Cox, Susan F.

Spratt, Neil J.

Hogan, Lisa

Aleksoska, Elena

van Raay, Leena

Liberatore, Gabriel T.

Batchelor, Peter E.

Howells, David W. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Med, Heidelberg, Vic 3084, Australia

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2010年 / 30卷 / 04期

关键词：

aging; diabetes mellitus; hypertension; experimental; rats; SHR; stroke; TISSUE-PLASMINOGEN ACTIVATOR; FOCAL CEREBRAL-ISCHEMIA; ADMISSION HYPERGLYCEMIA; OCCLUSION; MORTALITY; MODELS; ARTERY; RISK;

D O I：

10.1038/jcbfm.2009.273

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Animal models of ischemic stroke often neglect comorbidities common in patients. This study shows the feasibility of inducing stroke by 2 h of thread occlusion of the middle cerebral artery in aged (56 week old) spontaneously hypertensive rats (SHRs) with both acute (2 weeks) and chronic (36 weeks) diabetes. After modifying the streptozotocin dosing regimen to ensure that old SHRs survived the induction of diabetes, few died after induction of stroke. Induction of stroke is feasible in rats with multiple comorbidities. Inclusion of such comorbid animals may improve translation from the research laboratory to the clinic. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 729-733; doi:10.1038/jcbfm.2009.273; published online 13 January 2010

引用

页码：729 / 733

页数：5

共 20 条

[1] Risk reduction strategies in ischaemic stroke - The role of antiplatelet therapy [J].