Functional specialization of the primate frontal cortex during decision making

被引:95
作者
Lee, Daeyeol
Rushworth, Matthew F. S.
Walton, Mark E.
Watanabe, Masataka
Sakagami, Masamichi
机构
[1] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA
[2] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England
[3] Tokyo Metropolitan Inst Neurosci, Dept Psychol, Tokyo 1838526, Japan
[4] Tamaga Univ, Brain Sci Res Inst, Tokyo, Japan
基金
英国医学研究理事会;
关键词
reinforcement learning; reward; cingulate cortex; prefrontal cortex; orbitofrontal cortex; neuroeconomics;
D O I
10.1523/JNEUROSCI.1561-07.2007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Economic theories of decision making are based on the principle of utility maximization, and reinforcement-learning theory provides computational algorithms that can be used to estimate the overall reward expected from alternative choices. These formal models not only account for a large range of behavioral observations in human and animal decision makers, but also provide useful tools for investigating the neural basis of decision making. Nevertheless, in reality, decision makers must combine different types of information about the costs and benefits associated with each available option, such as the quality and quantity of expected reward and required work. In this article, we put forward the hypothesis that different subdivisions of the primate frontal cortex may be specialized to focus on different aspects of dynamic decision-making processes. In this hypothesis, the lateral prefrontal cortex is primarily involved in maintaining the state representation necessary to identify optimal actions in a given environment. In contrast, the orbitofrontal cortex and the anterior cingulate cortex might be primarily involved in encoding and updating the utilities associated with different sensory stimuli and alternative actions, respectively. These cortical areas are also likely to contribute to decision making in a social context.
引用
收藏
页码:8170 / 8173
页数:4
相关论文
共 59 条
[1]   Contrasting effects of reward expectation on sensory and motor memories in primate prefrontal neurons [J].
Amemori, Ken-ichi ;
Sawaguchi, Toshiyuki .
CEREBRAL CORTEX, 2006, 16 (07) :1002-1015
[2]   Meeting of minds: the medial frontal cortex and social cognition [J].
Amodio, DM ;
Frith, CD .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (04) :268-277
[3]  
[Anonymous], 1944, THEORY GAMES EC BEHA
[4]   The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism [J].
Bachevalier, J ;
Loveland, KA .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2006, 30 (01) :97-117
[5]   Prefrontal cortex and decision making in a mixed-strategy game [J].
Barraclough, DJ ;
Conroy, ML ;
Lee, D .
NATURE NEUROSCIENCE, 2004, 7 (04) :404-410
[6]   Emotion, decision making and the orbitofrontal cortex [J].
Bechara, A ;
Damasio, H ;
Damasio, AR .
CEREBRAL CORTEX, 2000, 10 (03) :295-307
[7]  
BUTTER C M, 1972, Acta Neurobiologiae Experimentalis (Warsaw), V32, P525
[8]  
Camerer C., 2003, BEHAV GAME THEORY
[9]   The computational neurobiology of learning and reward [J].
Daw, ND ;
Doya, K .
CURRENT OPINION IN NEUROBIOLOGY, 2006, 16 (02) :199-204
[10]   Monkeys pay per view: Adaptive valuation of social images by rhesus macaques [J].
Deaner, RO ;
Khera, AV ;
Platt, ML .
CURRENT BIOLOGY, 2005, 15 (06) :543-548