A summary of the post-licensure surveillance initiatives for GARDASIL/SILGARD®

被引：42

作者：

Bonanni, Paolo ^{[2
]}

Cohet, Catherine ^{[3
]}

Kjaer, Susanne K. ^{[4
,5
]}

Latham, Nina B. ^{[3
]}

Lambert, Paul-Henri ^{[6
]}

Reisinger, Keith ^{[7
]}

Haupt, Richard M. ^{[1
]}

机构：

[1] Merck Res Labs, West Point, PA USA

[2] Univ Florence, Florence, Italy

[3] Sanofi Pasteur MSD, Lyon, France

[4] Univ Copenhagen, Rigshosp, Gynecol Clin, DK-2100 Copenhagen, Denmark

[5] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[6] Ctr Vaccinol, Geneva, Switzerland

[7] Primary Phys Res, Pittsburgh, PA USA

来源：

VACCINE | 2010年 / 28卷 / 30期

关键词：

HPV vaccine; Monitoring; Post-licensure; HUMAN-PAPILLOMAVIRUS; QUADRIVALENT VACCINE; HPV VACCINATION; CERVICAL-CANCER; IMMUNIZATION; POPULATION; PREVALENCE; WOMEN; WARTS;

D O I：

10.1016/j.vaccine.2010.04.070

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

GARDASIL (R) has been shown to reduce the incidence of pre-cancerous cervical, vulvar, and vaginal lesions, and external genital warts causally related to HPV6/11/16/18. Because of its expected public health benefit on reduction of cervical cancer and other HPV-related diseases, this vaccine has been rapidly implemented in the routine vaccination programs of several countries. It is therefore essential to assess its impact and safety through post-licensure surveillance programs. Here, we present a summary of 16 post-licensure safety and impact studies across 20 countries. These studies address general safety, including autoimmune disorders, long-term effectiveness, and type replacement. A summary of the surveillance efforts of the Unites States Centers for Disease Control and Prevention can be found in the accompanying article by Markowitz et al. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4719 / 4730

页数：12

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