Genetic modifiers of atherosclerosis in mice

被引：121

作者：

Knowles, JW

Maeda, N

机构：

[1] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2000年 / 20卷 / 11期

关键词：

apoE; LDL receptor; hypertension; inflammation; diabetes;

D O I：

10.1161/01.ATV.20.11.2336

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is a complex, multifactorial disease with both genetic and environmental determinants. Experimental investigation of the effects of these determinants on the development and progression of atherosclerosis has been greatly facilitated by the use of targeted mouse models of the disease, particularly those resulting from the absence of functional genes for apolipoprotein E or the low density lipoprotein receptor (LDLR). This review focuses on the influence on atherosclerosis of combining apoE or LDLR deficiencies with factors affecting atherogenesis, including (1) inflammatory processes, (2) glucose metabolism, (3) blood pressure, and (4) coagulation and fibrinolysis. We also discuss the general problem of using the mouse to test the effects on atherogenesis of human polymorphic variations and future ways of enhancing the usefulness of these mouse models.

引用

收藏

页码：2336 / 2345

页数：10

相关论文

共 114 条

[1] Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1 [J].

Abe, H ;

Yamada, N ;

Kamata, K ;

Kuwaki, T ;

Shimada, M ;

Osuga, J ;

Shionoiri, F ;

Yahagi, N ;

Kadowaki, T ;

Tamemoto, H ;

Ishibashi, S ;

Yazaki, Y ;

Makuuchi, M .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (08) :1784-1788

[2] Early neonatal death in mice homozygous for a null allele of the insulin receptor gene [J].

Accili, D ;

Drago, J ;

Lee, EJ ;

Johnson, MD ;

Cool, MH ;

Salvatore, P ;

Asico, LD ;

Jose, PA ;

Taylor, SI ;

Westphal, H .

NATURE GENETICS, 1996, 12 (01) :106-109

[3] Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice [J].

Aiello, RJ ;

Bourassa, PAK ;

Lindsey, S ;

Weng, WF ;

Natoli, E ;

Rollins, BJ ;

Milos, PM .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (06) :1518-1525

[4]

Aji W, 1997, CIRCULATION, V95, P430

[5]

[Anonymous], 1999, WORLD HLTH REP 1999

[6] ALTERNATIVE PATHWAY OF INSULIN SIGNALING IN MICE WITH TARGETED DISRUPTION OF THE IRS-1 GENE [J].

ARAKI, E ;

LIPES, MA ;

PATTI, ME ;

BRUNING, JC ;

HAAG, B ;

JOHNSON, RS ;

KAHN, CR .

NATURE, 1994, 372 (6502) :186-190

[7] EFFECT OF COARCTATION ON MATRIX CONTENT OF EXPERIMENTAL AORTIC ATHEROSCLEROSIS - RELATION TO LOCATION, PLAQUE SIZE AND BLOOD-PRESSURE [J].

BARON, BW ;

GLAGOV, S ;

GIDDENS, DP ;

ZARINS, CK .

ATHEROSCLEROSIS, 1993, 102 (01) :37-49

[8] Strategies for studying cardiovascular phenotypes in genetically manipulated mice [J].

Becker, KD ;

Gottshall, KR ;

Chien, KR .

HYPERTENSION, 1996, 27 (03) :495-501

[9] EFFICACY OF TICLOPIDINE AND ASPIRIN FOR PREVENTION OF REVERSIBLE CEREBROVASCULAR ISCHEMIC EVENTS - THE TICLOPIDINE ASPIRIN STROKE STUDY [J].

BELLAVANCE, A .

STROKE, 1993, 24 (10) :1452-1457

[10] A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice [J].

Boisvert, WA ;

Santiago, R ;

Curtiss, LK ;

Terkeltaub, RA .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (02) :353-363

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