'Small' talk:: Opa proteins as mediators of Neisseria-host-cell communication

被引:86
作者
Hauck, CR
Meyer, TF
机构
[1] Univ Wurzburg, Zentrum Infektionsforsch, Wurzburg, Germany
[2] Max Planck Inst Infect Biol, Dept Mol Biol, Berlin, Germany
[3] Max Planck Inst Infektionsbiol, Abt Mol Biol, D-10117 Berlin, Germany
关键词
D O I
10.1016/S1369-5274(03)00004-3
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Opa proteins are variable outer membrane proteins of Neisseria gonorrhoeae and Neisseria meningitidis that mediate tight interaction of these pathogens with human cells. They have emerged as a paradigm of a bacterial toolbox allowing recognition of different host receptors and orchestrating the cell type tropism displayed by pathogenic Neisseriae. Recent work has highlighted the molecular basis of Opa-protein-host-receptor interaction and has shed new light on the functional consequences of this interaction with regard to bacterial attachment, invasion, and responses elicited in particular host cells.
引用
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页码:43 / 49
页数:7
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