Real-time magnetic resonance imaging-guided brachytherapy in the treatment of selected patients with clinically localized prostate cancer

Background and Purpose: A real-time three-dimensional magnetic resonance imaging (MRI)-guided implant technique has been designed and implemented. This report summarizes the dosimetry achieved and the acute morbidity in the first patients. Patients and Methods: To date, 43 patients with clinical stage T1cNxMo prostate cancer, serum prostate specific antigen <10 ng/mL, and biopsy Gleason score no higher than 3 + 4 have been treated. The procedure was performed using an open magnet, with axial T-1-weighted and fast spin echo images. The prescribed minimum radiation dose to the peripheral zone was 160 Gy, The total activity implanted ranged from 18.8 to 47.5 mCi using 43 to 120 (median 80) I-125 seeds. Dosimetric analyses were performed intraoperatively in real time for the tumor, anterior rectal wall, and prostatic urethra. Results: The percent of the clinical target volume receiving the prescription dose was 89% to 99% (median 96%), Using a conservative estimate of 164 Gy, no more than 9% of the urethral volume exceeded the tolerated dose. Using an estimated tolerated dose of 82 Gy, 30% to 100% (median 68%) of the anterior rectal wall volume was within the dose limit. Thirty-nine patients voided spontaneously within 3 hours of Foley catheter discontinuation, although four patients required recatheterization for a period, No patient reported gastrointestinal or sexual dysfunction during the first postoperative month. Conclusion: A real-time MR-guided technique can achieve a minimum of 89% coverage of the tumor volume while maintaining the prostatic urethra and most of the anterior rectal wall below tolerance levels, Acute morbidity was minimal, Further follow-up is needed to ascertain the impact on cancer control and quality of life.