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Intrathecal administration of a new nitric oxide donor, NOC-18, produces acute thermal hyperalgesia in the rat
被引:35
作者:
Inoue, T
[1
]
Mashimo, T
[1
]
Shibuta, S
[1
]
Yoshiya, I
[1
]
机构:
[1] Osaka Univ, Sch Med, Dept Anesthesiol, Osaka 565, Japan
关键词:
nitric oxide;
NO-releasing compounds;
nociception;
hyperalgesia;
cyclic GMP;
N-nitro-L-arginine methyl ester;
methylene blue;
hemoglobin;
spinal cord;
D O I:
10.1016/S0022-510X(97)00188-3
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
A nitric oxide releasing compound, NOC-18, was injected intrathecally in order to determine the role of NO in spinal nociceptive mechanisms in rats. The nociceptive threshold was evaluated by the radiant heat tail-flick test. The effects of intrathecal injection of N-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor; methylene blue (MB), a soluble guanylate cyclase inhibitor and hemoglobin (Hb), an NO scavenger, on the nociceptive threshold were measured in the presence and absence of 0.1, 1 and 10 mu g of NOC-18. The results were compared with a control group of rats which were injected with the same volume of normal saline. NOC-18 caused a dose-dependent curtailment of the tail-flick latency during the period from 15 to 150 min. L-NAME, MB and Hb all produced prolongation of the tail-flick latency during the same time period. The hyperalgesia induced by this concentration range of NOC-18 was completely blocked by Hb, but was not affected by either L-NAME or MB. These findings indicate that NO plays a direct role in thermal hyperalgesia in the spinal cord, and that an another pathway in addition to the NO-cGMP pathway may be involved. (C) 1997 Elsevier Science B.V.
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页码:1 / 7
页数:7
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