Synthesis of ene-1,1-diamines and pyrrolo[1,2-a]imidazolediones by 4,5-dihydroimidazole N-oxide cycloaddition and isoxazoline ring opening

被引：28

作者：

Jones, RCF ^{[1
]}

Martin, JN

Smith, P

Gelbrich, T

Light, ME

Hursthouse, MB

机构：

[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] Open Univ, Dept Chem, Milton Keynes MK7 6AA, Bucks, England

[3] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

[4] Univ Southampton, Dept Chem, EPSRC Natl Crystallog Serv, Southampton SO17 1BJ, Hants, England

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 19期

关键词：

D O I：

10.1039/b005530l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dihydroimidazole N-oxides 1 undergo 1,3-dipolar cycloaddition with alkyne dipolarophiles and the cycloadducts suffer isoxazoline N-O bond cleavage to afford ene-1,1-diamines, with subsequent cyclisation to pyrrolo[1,2-a]imidazole-5,6-diones if possible.

引用

页码：1949 / 1950

页数：2

共 9 条

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