Fragile sites: Breaking up over a slowdown

被引：36

作者：

Cimprich, KA ^{[1
]}

机构：

[1] Stanford Univ, Dept Mol Pharmacol, Stanford, CA 94305 USA

来源：

CURRENT BIOLOGY | 2003年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0960-9822(03)00158-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Common fragile sites are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Recent data suggest that these sites depend on the checkpoint kinase ATR to maintain their stability.

引用

页码：R231 / R233

页数：3

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