Novel human topoisomerase I inhibitors, topopyrones A, B, C and D - II. Structure elucidation

被引：19

作者：

Ishiyama, D

Kanai, Y

Senda, H

Iwatani, W

Takahashi, H

Konno, H

Kanazawa, S

机构：

[1] Kaken Pharmaceut CO LTD, Metab Res, Fujieda, Shizuoka 4268646, Japan

[2] Inst Biotechnol Appl Soil Eumycetes, Senbo Ku, Akita 0192112, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 09期

关键词：

D O I：

10.7164/antibiotics.53.873

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spectral analysis of the chemical derivatives. These compounds are an anthraquinone type containing a fused 1,4-pyrone moiety. Topopyrones A and B contain a chlorine atom, however C and D do not. It was suggested that topopyrones B and D are converted from topopyrones A and C, respectively by Wessely-Moser type rearrangement.

引用

页码：873 / 878

页数：6

共 7 条

[1]

JAIN AC, 1980, INDIAN J CHEM B, V19, P101

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