Environmental risk factors in multiple sclerosis aetiology

被引:226
作者
Marrie, RA [1 ]
机构
[1] Cleveland Clin Fdn, Mellen Ctr MS Treatment & Res U10, Cleveland, OH 44195 USA
关键词
D O I
10.1016/S1474-4422(04)00933-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The epidemiology of multiple sclerosis (MS) has been intensively studied. It is conceptualised as a complex disease in which genetic and environmental factors act together to cause disease. There are temporal and geographic variations in disease risk, and risk of disease may be affected by migration between regions of differing risk. Numerous potential causal factors including infection, immunisations, physical and emotional stressors, climate, diet, and occupational exposures have been studied using various observational study designs. Thus far, no single environmental exposure has been consistently identified as a causal factor in MS, but sufficient data have accumulated that causal pathways should be postulated and tested. This review will focus on the environmental epidemiology of MS.
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收藏
页码:709 / 718
页数:10
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