Modular Mo-based catalysts for efficient asymmetric olefin metathesis. Catalytic enantioselective synthesis of cyclic ethers and acetals

被引：58

作者：

Weatherhead, GS

Houser, JH

Ford, JG

Jamieson, JY

Schrock, RR

Hoveyda, AH ^{[1
]}

机构：

[1] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA

[2] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 49期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

asymmetric catalysis; enantioselective olefin metathesis; modular chiral catalysts;

D O I：

10.1016/S0040-4039(00)01690-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral Mo-based complexes 1-3 promote the catalytic enantioselective ring-closing metathesis of various polyenes to afford unsaturated furans, pyrans and siloxanes efficiently and in high ee (70-98% ee). The structural modularity of this class of chiral catalysts plays a critical role in these studies. Modification of the diolate or imido moities of these chiral catalysts gives rise to a range of complexes that can be screened for higher reactivity and/or enantioselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9553 / 9559

页数：7

共 24 条

[1] Catalytic enantioselective ring-closing metathesis by a chiral biphen-Mo complex [J].