Parc-ing p53 in the cytoplasm

被引：38

作者：

Kastan, MB

Zambetti, GP

机构：

[1] St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Biochem, Memphis, TN 38105 USA

来源：

CELL | 2003年 / 112卷 / 01期

关键词：

D O I：

10.1016/S0092-8674(02)01281-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nikolaev et al. (this issue of Cell) report the identification of a parkin-like protein, Parc, and its role in anchoring the tumor suppressor protein p53 in the cytoplasm reveals yet another level of control of p53 function. Regulation of the subcellular localization of p53 by Parc may serve as a novel target in treatment of certain types of tumors.

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页码：1 / 2

页数：2

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