Antibacterial Activity of Ecklonia cava Against Methicillin-Resistant Staphylococcus aureus and Salmonella spp.

被引：71

作者：

Choi, Jang-Gi ^{[1
]}

Kang, Ok-Hwa ^{[1
]}

Brice, Obiang-Obounou ^{[1
]}

Lee, Young-Seob ^{[1
]}

Chae, Hee-Sung ^{[1
]}

Oh, You-Chang ^{[1
]}

Sohn, Dong-Hwan

Park, Hyun ^{[2
]}

Choi, Han-Gil ^{[3
,4
]}

Kim, Se-Gun ^{[5
]}

Shin, Dong-Won ^{[6
]}

Kwon, Dong-Yeul ^{[1
]}

机构：

[1] Wonkwang Univ, Wonkwang Oriental Med Res Inst, Dept Oriental Pharm, Coll Pharm, Iksan 570749, Jeonbuk, South Korea

[2] Wonkwang Univ, Coll Med, Iksan 570749, Jeonbuk, South Korea

[3] Wonkwang Univ, Fac Biol Sci, Iksan 570749, Jeonbuk, South Korea

[4] Wonkwang Univ, Inst Biotechnol, Iksan 570749, Jeonbuk, South Korea

[5] Chungnam Natl Univ, Coll Pharm, Taejon, South Korea

[6] Sunchon Natl Univ, Dept Oriental Med Resources, Iksan, Jeonnam, South Korea

来源：

FOODBORNE PATHOGENS AND DISEASE | 2010年 / 7卷 / 04期

关键词：

IN-VITRO ACTIVITIES; BROWN ALGA; PHLOROTANNINS; COMBINATION; STOLONIFERA; ANTIMICROBIALS; GENTAMICIN; DAPTOMYCIN; EXTRACTS; STRAINS;

D O I：

10.1089/fpd.2009.0434

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Ecklonia cava is a brown alga (Laminariales, Phaeophyta) growing on the subtidal rocky shores of Korea. It has antioxidant, antidiarrhea, and anticoagulant effects. In this study, the antimicrobial activity of E. cava EtOH extract and its fractions (n-hexane, CH2Cl2, EtOAc, n-BuOH, and H2O) were investigated against methicillin-resistant Staphylococcus aureus and Salmonella spp. The E. cava EtOAc fraction showed good antibacterial activity against all bacteria. Eckol isolated from E. cava EtOAc fraction showed antimicrobial activity against all the tested strains. The minimum inhibitory concentration of eckol against S. aureus strains ranged from 125 to 250 mu g/mL and 125 to 250 mu g/mL for Salmonella strains. The fraction inhibitory concentration index of eckol in combination with ampicillin ranged from 0.31 to 0.5, indicating remarkable synergism against S. aureus. However, against Salmonella gallinarum ATCC 9184 and Salmonella typhimurium, it ranges from 0.75 to 1.0. The combinations of eckol + ampicillin exhibited improved inhibition of S. aureus and Salmonella with synergy or additive effect. We suggest that eckol ingredients of the E. cava against S. aureus and Salmonella have antibacterial activity.

引用

页码：435 / 441

页数：7

共 32 条

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