Hemorrhagic ocular complications associated with the use of systemic thrombolytic agents

Objective: This study aimed to report th ree patients with hemorrhagic ocular and orbital complications associated with the use of systemic thrombolytic agents. Design: The study design was a retrospective small case series. Participants: Three eyes of three patients were studied. Intervention: Surgical procedures to reduce intraocular pressure or relieve optic nerve compression were performed. Main Outcome Measures: Visual acuity and intraocular pressure were measured. Results: Three patients received an intravenous thrombolytic agent on diagnosis of an acute myocardial infarction, One patient had a spontaneous suprachoroidal hemorrhage develop with secondary acute angle closure glaucoma shortly after receiving tissue plasminogen activator, Another patient had an orbital hemorrhage develop on receiving tissue plasminogen activator 4 days after an uncomplicated cataract extraction, The third patient experienced an orbital hemorrhage while receiving streptokinase 1 day after undergoing an external levator resection. Two patients suffered significant visual loss due to glaucoma or compressive optic neuropathy. Conclusions: The onset of eye pain or visual loss after the administration of a systemic thrombolytic agent should alert the physician to the possibility of an ocular or adnexal hemorrhage, Prompt diagnosis and treatment can improve the likelihood of a favorable visual outcome.