Microbial hydroxylation of 2-cycloalkylbenzoxazoles .3. Determination of product enantiomeric excess and cleavage of benzoxazoles

被引：18

作者：

deRaadt, A ^{[1
]}

Griengl, H ^{[1
]}

Petsch, M ^{[1
]}

Plachota, P ^{[1
]}

Schoo, N ^{[1
]}

Weber, H ^{[1
]}

Braunegg, G ^{[1
]}

Kopper, I ^{[1
]}

Kreiner, M ^{[1
]}

Zeiser, A ^{[1
]}

机构：

[1] GRAZ TECH UNIV,INST BIOTECHNOL,A-8010 GRAZ,AUSTRIA

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 02期

关键词：

D O I：

10.1016/0957-4166(96)00032-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An HPLC-system to measure the e.e. of trans-3-(benz-1, 3-oxazol-2-yl)cyclopentan-1-ol 6, cis-3-(benz-1, 3-oxazol-2-yl)cyclopentan-1-ol 38, 3-(benz-1, 3-oxazol-2-yl)cyclopentan-1-one 8 and 2-(benz-1, 3-oxazol-2-yl)cyclopentan-1-ol 7 simultaneously in the fermentation mixture of the substrate 2-cyclopentyl-1, 3-benzoxazole 5 with Cunninghamella blakesleeana DSM 1906 is presented. The scope and limitations of the benzoxazole cleavage reactions is discussed.

引用

页码：491 / 496

页数：6

共 11 条

[1]

[Anonymous], COMMUNICATION

[2] NUCLEAR MAGNETIC-RESONANCE ENANTIOMER REAGENTS - CONFIGURATIONAL CORRELATIONS VIA NUCLEAR MAGNETIC-RESONANCE CHEMICAL-SHIFTS OF DIASTEREOMERIC MANDELATE, O-METHYLMANDELATE, AND ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETATE (MTPA) ESTERS [J].