A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?

被引：302

作者：

Knapska, E

Kaczmarek, L

机构：

[1] M Nencki Inst Expt Biol, Dept Mol & Cellular Neurobiol, PL-02093 Warsaw, Poland

[2] M Nencki Inst Expt Biol, Dept Neurophysiol, PL-02093 Warsaw, Poland

来源：

PROGRESS IN NEUROBIOLOGY | 2004年 / 74卷 / 04期

关键词：

D O I：

10.1016/j.pneurobio.2004.05.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Zif268 is a transcription regulatory protein, the product of an immediate early gene. Zif268 was originally described as inducible in cell cultures; however, it was later shown to be activated by a variety of stimuli, including ongoing synaptic activity in the adult brain. Recently, mice with experimentally mutated zif268 gene have been obtained and employed in neurobiological research. In this review we present a critical overview of Zif268 expression patterns in the naive brain and following neuronal stimulation as well as functional data with Zif268 mutants. In conclusion, we suggest that Zif268 expression and function should be considered in a context of neuronal activity that is tightly linked to neuronal plasticity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：183 / 211

页数：29

共 234 条

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