A tentative kinetic model for chiral amplification in autocatalytic alkylzinc additions

被引：59

作者：

Buhse, T ^{[1
]}

机构：

[1] Univ Autonoma Estado Morelos, Ctr Invest Quim, Cuernavaca 62210, Morelos, Mexico

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(03)00128-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A simplified kinetic model is proposed to describe stereoselective autocatalysis in specific alkylzinc additions. The model is based on current experimental knowledge and by the use of exclusively mono- or bimolecular processes attempting a chemically and kinetically realistic description. The underlying dynamics were expressed in terms of a template-directed self-replication in which a zinc alkoxide dimer acts as the active autocatalytic species. The model was shown to reproduce previously obtained kinetic data well, to address to the phenomenon of chiral amplification in a semi-quantitative manner, and to enlighten the cause of the effect of the initial enantiomeric excess on the globally observed kinetics. Amplification of enantiomeric excess occurs by considering a homogeneous and entirely symmetric reaction network. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1055 / 1061

页数：7

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