Reperfusion injury: Does it exist?

被引：97

作者：

Gross, Garrett J. ^{[1
]}

Auchampach, John A. ^{[1
]}

机构：

[1] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2007年 / 42卷 / 01期

关键词：

reperfusion injury; adenosine; opioids; postconditioning; heart; ischemia/reperfusion;

D O I：

10.1016/j.yjmcc.2006.09.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is well established that reperfusion of the heart is the optimal method of salvaging previously ischemic myocardium. However, the idea of reperfusion injury, i.e. injury caused by the process of reperfusion per se, still remains a controversial issue. In this review, we present mounting evidence supporting the concept that reperfusion injury exists, based on work conducted with adenosine and opioid receptor ligands, and the discovery of two new concepts regarding reperfusion injury: 'postconditioning' (POC) and the reperfusion injury salvage kinase (RISK) signaling pathway. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：12 / 18

页数：7

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