Use of the herpes amplicon system as a vehicle for somatic gene transfer

被引：6

作者：

Brooks, AI

Halterman, MW

Federoff, HJ

机构：

[1] UNIV ROCHESTER, SCH MED & DENT, DEPT NEUROL, ROCHESTER, NY 14642 USA

[2] UNIV ROCHESTER, SCH MED & DENT, DEPT MED, ROCHESTER, NY 14642 USA

[3] UNIV ROCHESTER, SCH MED & DENT, DEPT MICROBIOL & IMMUNOL, ROCHESTER, NY 14642 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1997年 / 27卷 / 01期

关键词：

herpes simplex; virus; gene transfer; viral packaging;

D O I：

10.1016/S0169-409X(97)00020-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The study of herpes virus biology has produced two vector delivery strategies which exploit the highly evolved neuronal tropism and life cycle regulation exhibited by this class of viruses. Amplicon and recombinant herpes simplex virus systems show promise for use in gene transfer to the nervous system and although neither Vector has been used in clinical trials to date, their application to gene delivery and perturbation of neuronal physiology have been well established. We will review the properties of the herpes amplicon system, and demonstrate its utility in neuroscience applications. (C) 1997 Elsevier Science B.V.

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收藏

页码：29 / 39

页数：11

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