Neuroprotective effects of 2,4-dimethoxybenzylidene anabaseine (DMXB) and tetrahydroaminoacridine (THA) in neocortices of nucleus basalis lesioned rats

被引：33

作者：

Meyer, EM

King, MA

Meyers, C

机构：

[1] Univ Florida, Coll Med, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA

[2] Univ Florida, Coll Med, VA Med Ctr, Gainesville, FL 32610 USA

[3] Univ Florida, Coll Med, Dept Neurosci, Gainesville, FL 32610 USA

来源：

BRAIN RESEARCH | 1998年 / 786卷 / 1-2期

关键词：

choline acetyltransferase; neocortical atrophy; nissl-staining; trans-synaptic; nicotinic;

D O I：

10.1016/S0006-8993(97)00300-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The nicotinic alpha 7 agonist dimethoxybenzilidene anabaseine (DMXB) and cholinesterase inhibitor tetrahydroaminoacridine (THA) were investigated in a trans-synaptic model for neocortical atrophy and degeneration following nucleus basalis lesions. Bilateral lesions reduced parietal neuronal density in layers LI-V 8 months later. DMXB administered i.p. daily to rats for 3 months attenuated this loss in layers II-V at a 1 mg/kg i.p. dose. A lower, 0.2 mg/kg i.p. dose, was neuroprotective in layer IV only. THA (1 mg/kg i.p.) also protected against neocortical Nissl-staining deficits. (C) 1998 Elsevier Science B.V.

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收藏

页码：252 / 254

页数：3

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