A general synthesis of 2′-deoxy-2′-[18F]fluoro-1-β-D-arabinofuranosyluracil and its 5-substituted nucleosides

被引：54

作者：

Alauddin, MM ^{[1
]}

Conti, PS ^{[1
]}

Fissekis, JD ^{[1
]}

机构：

[1] Univ So Calif, PET Imaging Sci Ctr, Los Angeles, CA 90033 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2003年 / 46卷 / 04期

关键词：

fluorine-18; nucleoside;

D O I：

10.1002/jlcr.637

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Several 2'-deoxy-2'-[ F-18]fluoro-1-beta-D-arabinofuranosyluracil derivatives have been synthesized. Coupling of1-bromo-2-deoxy-2-[F-18]fluoro-3,5-di-O-benzoyl-alpha-D-arabinofuranose 2 with protected uracil derivatives 3a-e followed by hydrolysis and high-performance liquid chromatography purification produced the radiolabeled nucleosides 4a-e in 15-30% yield (d. c.), > 99% radiochemical purity and 55.5-103.6 GBq/mumol specific activities. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：285 / 289

页数：5

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