Self-aggregates of deoxycholic acid modified chitosan as a novel carrier of adriamycin

被引：107

作者：

Lee, KY ^{[1
]}

Kim, JH ^{[1
]}

Kwon, IC ^{[1
]}

Jeong, SY ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Biomed Res Ctr, Seoul 130650, South Korea

来源：

COLLOID AND POLYMER SCIENCE | 2000年 / 278卷 / 12期

关键词：

chitosan; deoxycholic acid; self-aggregate; nanoparticle; adriamycin;

D O I：

10.1007/s003960000389

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregated suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2).

引用

页码：1216 / 1219

页数：4

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