Dystrophin-associated protein scaffolding in brain requires α-dystrobrevin

被引：16

作者：

Bragg, April D. ^{[1
]}

Das, Sonal S. ^{[1
]}

Froehner, Stanley C. ^{[1
]}

机构：

[1] Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA

来源：

NEUROREPORT | 2010年 / 21卷 / 10期

关键词：

dystrophin; glia; perivascular astrocyte; syntrophin; POSTSYNAPTIC MEMBRANE; MUSCULAR-DYSTROPHIES; BETA-DYSTROBREVIN; SYNTROPHIN; COMPLEX; UTROPHIN; FAMILY; MUSCLE; MEMBER; IDENTIFICATION;

D O I：

10.1097/WNR.0b013e32833b0a3b

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dystrophin and the alpha-dystrobrevins bind directly to the adapter protein syntrophin to form membrane-associated scaffolds. At the blood-brain barrier, alpha-syntrophin colocalizes with dystrophin and the alpha-dystrobrevins in perivascular glial endfeet and is required for localization of the water channel aquaporin-4. Earlier we have shown that localization of the scaffolding proteins gamma 2-syntrophin, alpha-dystrobrevin-2, and dystrophin to glial endfeet is also dependent on the presence of alpha-syntrophin. In this study, we show that the expression levels of alpha-syntrophin, gamma 2-syntrophin, and dystrophin at the blood-brain barrier are reduced in alpha-dystrobrevin-null mice. This is the first demonstration in which assembly of an astroglial protein scaffold containing syntrophin and dystrophin in perivascular astrocytes is dependent on the presence of alpha-dystrobrevin. NeuroReport 21:695-699 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：695 / 699

页数：5

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