Molecular characterization of an Enterovirus 71 causing neurological disease in Germany

被引：42

作者：

Kehle, J

Roth, B

Metzger, C

Pfitzner, A

Enders, G

机构：

[1] Lab G Enders & Partner, D-70193 Stuttgart, Germany

[2] Inst Virol Infectol & Epidemiol eV, D-70193 Stuttgart, Germany

[3] VIROTEST Prof Enders GmbH, Stuttgart, Germany

[4] Univ Hohenheim, Inst Genet, Dept Gen Virol, D-7000 Stuttgart, Germany

来源：

JOURNAL OF NEUROVIROLOGY | 2003年 / 9卷 / 01期

关键词：

B2; sublineage; Enterovirus; 71; Europe; neurological disease;

D O I：

10.1080/13550280390173364

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Enterovirus 71 (EV71) is mainly known as a cause of hand-foot-and-mouth disease (HFMD) but sometimes associated with neurological disease, even as fatal brainstem encephalitis. In Europe, EV71 infections are extremely rare, in contrast to the worldwide situation. This is the first report of molecular characterization of an EV71 strain isolated in Europe that had caused neurological disease. The german strain is closest related to sublineage B2 strains isolated in the United States, which where mainly associated with neurological disease. Phylogenetic analysis also showed that the strain must have been imported to Germany several years ago, and continues to circulate since then.

引用

页码：126 / 128

页数：3

共 8 条

[1] Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998 [J].