Genome-wide association study of hematological and biochemical traits in a Japanese population

被引：404

作者：

Kamatani, Yoichiro ^{[1
,2
]}

Matsuda, Koichi ^{[1
]}

Okada, Yukinori ^{[3
]}

Kubo, Michiaki ^{[4
]}

Hosono, Naoya ^{[4
]}

Daigo, Yataro ^{[1
,2
]}

Nakamura, Yusuke ^{[1
,5
]}

Kamatani, Naoyuki ^{[3
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome, Tokyo, Japan

[2] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Tokyo, Japan

[3] RIKEN, Lab Stat Anal, Kanagawa, Japan

[4] RIKEN, Lab Genotyping Dev, Kanagawa, Japan

[5] RIKEN, Ctr Genom Med, Kanagawa, Japan

来源：

NATURE GENETICS | 2010年 / 42卷 / 03期

关键词：

COMMON VARIABLE IMMUNODEFICIENCY; PLATELET GLYCOPROTEIN-IB; LOCI; VARIANTS; MUTATION; GENE; ERYTHROCYTE; PROTEIN; RISK; POLYMORPHISMS;

D O I：

10.1038/ng.531

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report genome-wide association studies for hematological and biochemical traits from similar to 14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels (P < 5 x 10(-8)). Of these, 46 associations were new to this study and 43 replicated previous reports. We compared these associated loci with those reported in similar GWAS in European populations. When the minor allele frequency was >10% in the Japanese population, 32 (94.1%) and 31 (91.2%) of the 34 hematological loci previously reported to be associated in a European population were replicated with P-values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated.

引用

页码：210 / U25

页数：7

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