Neurobiology -: Homeostasis or synaptic plasticity?

被引：19

作者：

Frégnac, Y ^{[1
]}

机构：

[1] Inst Alfred Fessard, CNRS, Equipe Cognisci, F-91198 Gif Sur Yvette, France

来源：

NATURE | 1998年 / 391卷 / 6670期

关键词：

D O I：

10.1038/35996

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Learning and memory are dependent on synaptic plasticity, through long-lasting changes in synaptic strengths. The two well-characterized forms of plasticity are long-term potentiation (LTP) and long-term depression (LTD). But one group has now discovered a completely different form of plasticity. Whereas LTP and LTD modulate the strength of synapses in a synapse-specific manner, the new form represents a more general regulation of the total synaptic strength of a neuron. And because it is bidirectional, it could have interesting computational properties.

引用

页码：845 / 846

页数：2

共 17 条

[1]

Abbott LF, 1997, SCIENCE, V275, P220, DOI 10.1126/science.275.5297.221

[2] Metaplasticity: The plasticity of synaptic plasticity [J].

Abraham, WC ;

Bear, MF .

TRENDS IN NEUROSCIENCES, 1996, 19 (04) :126-130

[3]

[Anonymous], HDB BRAIN THEORY NEU

[4] MECHANISM FOR A SLIDING SYNAPTIC MODIFICATION THRESHOLD [J].

BEAR, MF .

NEURON, 1995, 15 (01) :1-4

[5] THEORY FOR THE DEVELOPMENT OF NEURON SELECTIVITY - ORIENTATION SPECIFICITY AND BINOCULAR INTERACTION IN VISUAL-CORTEX [J].

BIENENSTOCK, EL ;

COOPER, LN ;

MUNRO, PW .

JOURNAL OF NEUROSCIENCE, 1982, 2 (01) :32-48

[6] Forward and backward propagation of dendritic impulses and their synaptic control in mitral cells [J].

Chen, WR ;

Midtgaard, J ;

Shepherd, GM .

SCIENCE, 1997, 278 (5337) :463-467

[7] Propagation of activity-dependent synaptic depression in simple neural networks [J].

Fitzsimonds, RM ;

Song, HJ ;

Poo, MM .

NATURE, 1997, 388 (6641) :439-448

[8] TARGET-DEPENDENT MORPHOLOGICAL SEGREGATION OF APLYSIA SENSORY OUTGROWTH INVITRO [J].

GLANZMAN, DL ;

KANDEL, ER ;

SCHACHER, S .

NEURON, 1991, 7 (06) :903-913

[9]

Hebb D. O., 1949, ORG BEHAV NEUROPHYSI

[10] PROPERTIES OF SYNAPTIC TRANSMISSION AT SINGLE HIPPOCAMPAL SYNAPTIC BOUTONS [J].

LIU, GS ;

TSIEN, RW .

NATURE, 1995, 375 (6530) :404-408

← 1 2 →