Metformin: From Mechanisms of Action to Therapies

被引：1091

作者：

Foretz, Marc ^{[1
,2
,3
]}

Guigas, Bruno ^{[4
,5
]}

Bertrand, Luc ^{[6
]}

Pollak, Michael ^{[7
,8
]}

Viollet, Benoit ^{[1
,2
,3
]}

机构：

[1] Inst Cochin, INSERM, U1016, Paris, France

[2] CNRS, UMR8104, Paris, France

[3] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[4] Leiden Univ Med Ctr, Dept Parasitol, Leiden, Netherlands

[5] Leiden Univ Med Ctr, Dept Mol Cell Biol, Leiden, Netherlands

[6] Catholic Univ Louvain, Inst Rech Expt & Clin, B-1200 Brussels, Belgium

[7] McGill Univ, Dept Oncol, Montreal, PQ, Canada

[8] McGill Univ, Jewish Gen Hosp, Segal Canc Ctr, Montreal, PQ H3T 1E2, Canada

来源：

CELL METABOLISM | 2014年 / 20卷 / 06期

关键词：

ACTIVATED PROTEIN-KINASE; MITOCHONDRIAL PERMEABILITY TRANSITION; ANTIDIABETIC DRUG METFORMIN; LEFT-VENTRICULAR FUNCTION; HEPATIC GLUCONEOGENESIS; HEART-FAILURE; CELL-DEATH; COMPLEX I; MYOCARDIAL-INFARCTION; MOLECULAR-MECHANISMS;

D O I：

10.1016/j.cmet.2014.09.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular diseases and cancer. However, the underlying mechanisms of action remain elusive. Convincing data place energy metabolism at the center of metformin's mechanism of action in diabetes and may also be of importance in cardiovascular diseases and cancer. Metformin-induced activation of the energy-sensor AMPK is well documented, but may not account for all actions of the drug. Here, we summarize current knowledge about the different AMPK-dependent and AMPK-independent mechanisms underlying metformin action.

引用

页码：953 / 966

页数：14

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