Vectors for the treatment of autoimmune disease

被引：28

作者：

Gould, DJ ^{[1
]}

Favorov, P ^{[1
]}

机构：

[1] Univ London, Queen Marys Med Sch, Barts & London, Bone & Joint Res Unit, London EC1M 6BQ, England

来源：

GENE THERAPY | 2003年 / 10卷 / 10期

关键词：

vectors; autoimmunity; regulated gene expression; targeting;

D O I：

10.1038/sj.gt.3302018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene therapy has been applied in a variety of experimental models of autoimmunity with some success. In this article, we outline recent developments in gene therapy vectors, discuss advantages and disadvantages of each, and highlight their recent applications in autoimmune models. We also consider progress in vector targeting and components for regulating transgene expression, which will both improve gene therapy safety and empower gene therapy to fullfil its potential as a therapeutic modality. In conclusion, we consider candidate vectors that satisfy requirements for application in the principal therapeutic strategies in which gene therapy will be applied to autoimmune conditions.

引用

页码：912 / 927

页数：16

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