Synthesis of DEFG ring of complestatin and chloropeptin I: Highly atropdiastereoselective macrocyclization by intramolecular Suzuki-Miyaura reaction

被引：52

作者：

Jia, Yanxing ^{[1
]}

Bois-Choussy, Micheele ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 12期

关键词：

D O I：

10.1021/ol070889p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed intramolecular Suzuki-Miyaura reaction of linear tripeptide (23) afforded the 16-membered DEFG ring of complestatin (23) in good yield with an excellent atropdiastereoselectivity. Acidic treatment of 3 triggers a stereospecific rearrangement leading to the corresponding DEFG ring 4 of chloropeptin I.

引用

页码：2401 / 2404

页数：4

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