Towards a blood-stage vaccine for malaria: Are we following all the leads?

被引：94

作者：

Good, MF ^{[1
]}

机构：

[1] Queensland Inst Med Res, Cooperat Res Ctr Vaccine Technol, Bancroft Ctr, Herston, Qld 4006, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2001年 / 1卷 / 02期

关键词：

D O I：

10.1038/35100540

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although the malaria parasite was discovered more than 120 years ago, it is only during the past 20 years, following the cloning of malaria genes, that we have been able to think rationally about vaccine design and development. Effective vaccines for malaria could interrupt the life cycle of the parasite at different stages in the human host or in the mosquito. The purpose of this review is to outline the challenges we face in developing a vaccine that will limit growth of the parasite during the stage within red blood cells - the stage responsible for all the symptoms and pathology of malaria. More than 15 vaccine trials have either been completed or are in progress, and many more are planned. Success in current trials could lead to a vaccine capable of saving more than 2 million lives per year.

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页码：117 / 125

页数：9

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